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Technology

Proprietary Technology

We’ve developed a technology, a microfluidic technology that offers a solution for easy and accurate Self Sampling.

Our Technology

Capitainer’s Technology

All Capitainer blood sampling cards are built on our technology. It uses a combination of paper, polymer microfluidics and thin water-soluble membranes to meter a fixed volume of blood. After applying blood to the inlet, a metering channel in the device is automatically filled and the blood is transferred to a pre-cut DBS paper disc. The metering mechanism employing thin dissolvable films was first demonstrated by G. Lenk et al 

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  • 10µL version

    In the 10µL version, one blood drop is added to the inlet and a double valve solution is applied where a thin dissolvable membrane opens up after blood application and removes excessive blood at the inlet. Subsequently, a second membrane opens up , allowing for transfer of the metered blood volume onto the sample collection disk at the outlet.

  • 50µL version

    The 50µL version applies a single valve solution with another filling mechanism, to allow application of multiple drops. The sample is allowed to dry forming a high quality sample suitable for quantitative analysis.

Evaluation Study

Manual Pipetting of Blood vs Capitainer® Collection
Experiment

  • EDTA-blood was collected from a coffee drinker by venous puncture
  • 25 µL of blood was applied to 20 Capitainer® channels
  • For reference 10 µL of blood was applied by manual displacement pipetting to 20 discs removed from Capitainer® devices
  • Caffeine concentration was measured in all samples by an accredited LC-MS/MS method

Result

  • Caffeine concentration coefficient of variation for Capitainer® was 2,84% vs 6,25% for manual pipetting

Source: Evaluation study by Dr Olof Beck, Analysis of caffeine by LC-MS/MS method. 2020 March 16. Similar results were obtained in a study by Spooner et al

Metering using the double valve technology applied in the Capitainer®B sampling card (previously called Capitainer®qDBS)